Article

Allele biased transcription factor binding across human brain regions gives mechanistic insight into eQTLs

2023-10-09

Abstract excerpt

<h4>Summary</h4> Transcription Factors (TFs) influence gene expression by facilitating or disrupting the formation of transcription initiation machinery at particular genomic loci. Because genomic localization of TFs is in part driven by TF recognition of DNA sequence, variation in TF binding sites can disrupt TF-DNA associations and affect gene regulation. To identify variants that impact TF binding in human bra...

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Literature Corpus work: 7d014bf5-57f2-5eac-beab-6a4c2b62d37a
DOI: 10.1101/2023.10.06.561245

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