Article

SETDB1 modulates the TGFβ response in Duchenne muscular dystrophy myotubes

2023-06-28

Abstract excerpt

<h4>SUMMARY</h4> Overactivation of the TGFβ signaling in Duchenne muscular dystrophy (DMD) is a major hallmark of disease progression, leading to fibrosis and muscle dysfunction. Here, we investigated the role of SETDB1, a histone lysine methyltransferase involved in muscle differentiation. Our data show that, following TGFβ induction, SETDB1 accumulates in the nuclei of healthy myotubes, while being already pres...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cec1e817-772d-5d8d-8404-d9e2961f2a22
DOI: 10.1101/2023.06.28.546840

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SETDB1 modulates the TGFβ response in Duchenne muscular dystrophy myotubesDOI 10.1101/2023.06.28.546840Read

Late-Stage Skeletal Muscle Transcriptome in Duchenne muscular dystrophy shows a BMP4-Induced Molecular SignatureSemantic proximity Read

Single nuclei/cell transcriptomics reveal DMD driven cell dynamics and mechanisms of fibroblast inflammatory tissue priming in human dystrophic muscleSemantic proximity Read

Smad8 Is Increased in Duchenne Muscular Dystrophy and Suppresses miR-1, miR-133a, and miR-133bSemantic proximity Read

USP18 is an essential regulator of muscle cell differentiation and maturationSemantic proximity Read

Long noncoding RNA H19X is a key mediator of TGF-β–driven fibrosisSemantic proximity Read

miR-486 is an epigenetic modulator of Duchenne muscular dystrophy pathologiesSemantic proximity Read

Spatial transcriptomics reveal markers of histopathological changes in Duchenne muscular dystrophy mouse modelsSemantic proximity Read

Histone modifications in Duchenne muscular dystrophy: pathogenesis insights and therapeutic implications.Semantic proximity Read

Setdb1 safeguards genome integrity in muscle stem cells to allow for regenerative myogenesis and inflammationSemantic proximity Read

Single cell RNA sequencing of human FAPs reveals different functional stages in Duchenne muscular dystrophySemantic proximity Read

The hallmarks of myotonic dystrophy type 1 muscle dysfunctionSemantic proximity Read

Dlk1-Dio3 cluster miRNAs regulate mitochondrial functions in Duchenne muscular dystrophySemantic proximity Read