Article

Spatial transcriptomics reveal markers of histopathological changes in Duchenne muscular dystrophy mouse models

2022-03-18

Abstract excerpt

Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene, leading to lack of dystrophin. Chronic muscle damage eventually leads to histological alterations in skeletal muscles. The identification of genes and cell types driving tissue remodeling is a key step to develop effective therapies. Here we use spatial transcriptomics in two DMD mouse models differing in disease severity to identify gene e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4f26c3a4-f4e3-584e-806d-4d231aac524f
DOI: 10.1101/2022.03.17.484699

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial transcriptomics reveal markers of histopathological changes in Duchenne muscular dystrophy mouse modelsDOI 10.1101/2022.03.17.484699Read

Unraveling the spatial landscape of Dystrophinopathies: a transcriptomic approach to Becker and Duchenne muscular dystrophiesSemantic proximity Read

A cellular and molecular spatial atlas of dystrophic muscleSemantic proximity Read

Spatial and Multiomic profiling of muscle regeneration dynamics in Duchenne Muscular DystrophySemantic proximity Read

Transcriptomic analysis of mdx mouse muscles reveals a signature of early human Duchenne muscular dystrophySemantic proximity Read

Single cell RNA sequencing of human FAPs reveals different functional stages in Duchenne muscular dystrophySemantic proximity Read

Late-Stage Skeletal Muscle Transcriptome in Duchenne muscular dystrophy shows a BMP4-Induced Molecular SignatureSemantic proximity Read

Muscle genome-wide expression profiling during disease evolution in mdx miceSemantic proximity Read

Compartment-specific remodeling of skeletal muscle in Duchenne muscular dystrophySemantic proximity Read

Distinct extracellular matrix states uncouple collagen accumulation from pathological fibrosis in Duchenne muscular dystrophySemantic proximity Read

Decoding Duchenne muscular dystrophy transcriptome to single nuclei level reveals clinical-genetic correlationsSemantic proximity Read

Muscle Spatial Transcriptomic Reveals Heterogeneous Profiles in Juvenile Dermatomyositis and Persistence of Abnormal Signature After RemissionSemantic proximity Read

Duchenne muscular dystrophy trajectory in R-DMDdel52 preclinical rat model identifies COMP as biomarker of fibrosisSemantic proximity Read