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The hallmarks of myotonic dystrophy type 1 muscle dysfunction

2 Dec 2020

Abstract excerpt

Myotonic dystrophy type 1 (DM1) is the most prevalent form of muscular dystrophy in adults and yet there are currently no treatment options. Although this disease causes multisystemic symptoms, it is mainly characterised by myopathy or diseased muscles, which includes muscle weakness, atrophy, and myotonia, severely affecting the lives of patients worldwide. On a molecular level, DM1 is caused by an expansion of...

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PMID: 33269537
DOI: 10.1111/brv.12674

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