Article

miR-486 is an epigenetic modulator of Duchenne muscular dystrophy pathologies

2021-06-15

Abstract excerpt

Duchenne muscular dystrophy (DMD) is an X-linked progressive muscle disorder resulting in muscle weakness and cardiomyopathy. MicroRNAs have been shown to play essential roles in muscle development, metabolism, and disease pathologies. We demonstrated that miR-486 expression is reduced in DMD muscles and its expression levels correlate with dystrophic disease severity. MicroRNA-486 knockout mice developed disrupt...

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Literature Corpus work: f5ee37e3-cf87-548f-b857-022dfae802e2
DOI: 10.1101/2021.06.14.448387

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