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Article

Long noncoding RNA H19X is a key mediator of TGF-β–driven fibrosis

30 Jun 2020

Abstract excerpt

TGF-β is a master regulator of fibrosis, driving the differentiation of fibroblasts into apoptosis-resistant myofibroblasts and sustaining the production of extracellular matrix (ECM) components. Here, we identified the nuclear long noncoding RNA (lncRNA) H19X as a master regulator of TGF-β-driven tissue fibrosis. H19X was consistently upregulated in a wide variety of human fibrotic tissues and diseases and was...

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PMID: 32603313
DOI: 10.1172/jci135439

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