Article

Late-Stage Skeletal Muscle Transcriptome in Duchenne muscular dystrophy shows a BMP4-Induced Molecular Signature

2024-04-25

Abstract excerpt

Duchenne muscular dystrophy (DMD) is a fatal X-linked recessive disease due to loss-of-function mutations in the DYSTROPHIN gene. DMD-related skeletal muscle wasting is typified by an aberrant immune response involving upregulation of TGFβ family of cytokines. We previously demonstrated that bone morphogenetic protein 4 (BMP4) is increased in DMD and BMP4 stimulation induces a 20-fold upregulation of Smad8 trans...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 88020995-b184-5230-bc94-f693df440e12
DOI: 10.1101/2024.04.19.590266

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Late-Stage Skeletal Muscle Transcriptome in Duchenne muscular dystrophy shows a BMP4-Induced Molecular SignatureDOI 10.1101/2024.04.19.590266Read

Muscle genome-wide expression profiling during disease evolution in mdx miceSemantic proximity Read

Smad8 Is Increased in Duchenne Muscular Dystrophy and Suppresses miR-1, miR-133a, and miR-133bSemantic proximity Read

Single cell RNA sequencing of human FAPs reveals different functional stages in Duchenne muscular dystrophySemantic proximity Read

Assessing Facioscapulohumeral Muscular Dystrophy through Comparative Analysis of Bulk and Single-Cell TranscriptomesSemantic proximity Read

Gene expression profiling in the early phases of DMD: a constant molecular signature characterizes DMD muscle from early postnatal life throughout disease progression.Semantic proximity Read

Transcriptomic analysis of paired healthy human skeletal muscles to identify modulators of disease severity in DMDSemantic proximity Read

Spatial transcriptomics reveal markers of histopathological changes in Duchenne muscular dystrophy mouse modelsSemantic proximity Read

Muscle transcriptome profiling reveals novel molecular pathways and biomarkers in laminin-α2 deficient patients.Semantic proximity Read

Comparative transcriptome analysis of muscular dystrophy models Large(myd), Dmd(mdx)/Large(myd) and Dmd(mdx): what makes them different?Semantic proximity Read

SETDB1 modulates the TGFβ response in Duchenne muscular dystrophy myotubesSemantic proximity Read

Identifying the hub genes for Duchenne muscular dystrophy and Becker muscular dystrophy by weighted correlation network analysisSemantic proximity Read

Transcriptome profiling identifies regulators of pathogenesis in collagen VI related muscular dystrophy.Semantic proximity Read