Article

Setdb1 safeguards genome integrity in muscle stem cells to allow for regenerative myogenesis and inflammation

2023-06-08

Abstract excerpt

<h4>ABSTRACT</h4> Modulations in chromatin structure orchestrate gene expression and direct stem cell fate. More specifically, the histone 3 lysine 9 Methyltransferase Setdb1 controls transcriptional repression to regulate pluripotency and self-renewal. While Setdb1 functions have been extensively studied in embryonic stem cells and in cancer cells, less is known on its role in adult stem cells in vivo . Here, w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1b5ec784-b263-5a43-bc11-8c0bd664eaac
DOI: 10.1101/2023.06.08.544190

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Setdb1 safeguards genome integrity in muscle stem cells to allow for regenerative myogenesis and inflammationDOI 10.1101/2023.06.08.544190Read

Defective plasticity in dermatomyositis patients muscle stem cells is associated with sustained intrinsic inflammatory signaling and disruption of the histone H3.3 chromatin loading pathwaySemantic proximity Read

Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic MusclesSemantic proximity Read

Genomic and Molecular Maps of Stemness and Malignant Regulatory SignaturesSemantic proximity Read

Epigenetic regulation of Wnt7b expression by the <i>cis</i> -acting long noncoding RNA lnc-Rewind in muscle stem cellsSemantic proximity Read

Regulation of human interferon signaling by transposon exonizationSemantic proximity Read

A reference single-cell transcriptomic atlas of human skeletal muscle tissue reveals bifurcated muscle stem cell populationsSemantic proximity Read

Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation.Semantic proximity Read

The Role of Histone Methyltransferase SETDB1 in Normal and Malignant HematopoiesisSemantic proximity Read

Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shorteningSemantic proximity Read

Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosisSemantic proximity Read

SETDB1 modulates the TGFβ response in Duchenne muscular dystrophy myotubesSemantic proximity Read

Epigenetic regulation of satellite cell fate during skeletal muscle regenerationSemantic proximity Read