Article

hDOT1L Links Histone Methylation to Leukemogenesis

2021-06-24

Abstract excerpt

Epigenetic modifications play an important role in human cancer. One such modification, histone methylation, contributes to human cancer through deregulation of cancer-relevant genes. The yeast Dot1 and its human counterpart, hDOT1L, methylate lysine 79 located within the globular domain of histone H3. Here we report that hDOT1L interacts with AF10, an MLL (mixed lineage leukemia) fusion partner involved in acute...

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Literature Corpus work: cd506583-28ef-5a78-81a3-861c7524b566
DOI: 10.17615/xez9-6921

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