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Article

Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast.

Nature communications - 16 Jan 2018

Lee Soyun, Oh Seunghee, Jeong Kwiwan, Jo Hyelim, Choi Yoonjung, Seo Hogyu David, Kim Minhoo, Choe Joonho, Kwon Chang Seob, Lee Daeyoup

Abstract excerpt

Dot1 (disruptor of telomeric silencing-1, DOT1L in humans) is the only known enzyme responsible for histone H3 lysine 79 methylation (H3K79me) and is evolutionarily conserved in most eukaryotes. Yeast Dot1p lacks a SET domain and does not methylate free histones and thus may have different actions with respect to other histone methyltransferases. Here we show that Dot1p displays histone chaperone activity and...

Topics

Chromatin
Gene Expression Regulation, Fungal
Histone Chaperones
Histone-Lysine N-Methyltransferase
Histones
Lysine
Mutation
Nuclear Proteins
Nucleosomes
Protein Binding
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae Proteins

Transcription, Genetic

Source

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Identifiers

PMID: 29339748
DOI: 10.1038/s41467-017-02759-8
PMCID: PMC5770421

Genes

SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29339748-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast.PMID 29339748Read ↗

Dot1p modulates silencing in yeast by methylation of the nucleosome core.Semantic proximity Read ↗

Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association.Semantic proximity Read ↗

DOT1L Complex Regulates Transcriptional Initiation in Human CellsSemantic proximity Read ↗

The mechanism of cross-talk between histone H2B ubiquitination and H3 methylation by Dot1LSemantic proximity Read ↗

The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure.Semantic proximity Read ↗

The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation.Semantic proximity Read ↗

Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae.Semantic proximity Read ↗

Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.Semantic proximity Read ↗

DOT1L limits RNAPII promoter-proximal pause release thus enabling Activation Induced Deaminase activity genome-wideSemantic proximity Read ↗

Antagonistic H3K79me-H3K9ac crosstalk determines elongation at housekeeping genes to promote pluripotencySemantic proximity Read ↗

H3K79 methylation and H3K36 tri-methylation synergistically regulate gene expression in pluripotent stem cellsSemantic proximity Read ↗

hDOT1L Links Histone Methylation to LeukemogenesisSemantic proximity Read ↗

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