Article
Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.
Proceedings of the National Academy of Sciences of the United States of America - 20 Sept 2011
Biswas Debabrata, Milne Thomas A, Basrur Venkatesha, Kim Jaehoon, Elenitoba-Johnson Kojo S J, Allis C David, Roeder Robert G
Abstract excerpt
A number of acute leukemias arise from fusion of the mixed lineage leukemia 1 protein (MLL) N terminus to a variety of fusion partners that have been reported to reside in one or more poorly defined complexes linked to transcription elongation through interactions with the histone H3-K79 methyltransferase DOT1 and positive transcription elongation factor b (P-TEFb). Here we first identify natural complexes...
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