Article

Selective targeting of an oncogenic <i>KRAS</i> mutant allele by CRISPR/Cas9 induces efficient tumor regression

2019-10-17

Abstract excerpt

<h4>Background</h4> KRAS is one of the most frequently mutated oncogenes in human cancers, but its activating mutations have remained undruggable due to its picomolar affinity for GTP/GDP and its smooth protein structure resulting in the absence of known allosteric regulatory sites. <h4>Results</h4> With the goal of treating mutated KRAS -driven cancers, two CRISPR systems, CRISPR-SpCas9 genome-editing system...

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Literature Corpus work: b272daa1-5bc7-5211-b9d8-872b12f570a1
DOI: 10.1101/807578

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