Article

Distinct mechanistic pathways of early tauopathy revealed by <i>MAPT</i> mutations

2026-02-16

Abstract excerpt

Tau pathology underlies a broad spectrum of neurodegenerative disorders, collectively termed tauopathies, yet these diseases exhibit striking heterogeneity in their biological mechanisms and clinical outcomes. The basis for this heterogeneity remains poorly understood. Here, we address this question using knock-in mouse models expressing two distinct frontotemporal dementia-associated tau mutations to define how d...

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Literature Corpus work: 78cbb838-d99a-5cf9-9ebe-9aaef53d16b3
DOI: 10.64898/2026.02.14.705716

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