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Article

Tau pathology epigenetically remodels the neuron-glial cross-talk in Alzheimer’s disease

21 Apr 2023

Abstract excerpt

The neuron-glia cross-talk is critical to brain homeostasis and is particularly affected by neurodegenerative diseases. How neurons manipulate the neuron-astrocyte interaction under pathological conditions, such as hyperphosphorylated tau, a pathological hallmark in Alzheimer's disease (AD), remains elusive. In this study, we identified excessively elevated neuronal expression of adenosine receptor 1 (Adora1 or...

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PMID: 37083538
DOI: 10.1126/sciadv.abq7105

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