Article

Ubiquitylome Rewiring by Bacterial E3 Ligases Reveals Multifaceted Host Subversion

2025-12-02

Abstract excerpt

<h4>ABSTRACT</h4> Salmonella enterica has evolved an arsenal of effector proteins secreted via type III secretion systems (T3SS) to manipulate host cell functions. Among these, the NEL family E3 ubiquitin ligases (SlrP, SspH1, and SspH2) are known to modulate immune signaling, but the breadth of their impact on the host ubiquitylome remains unexplored. In this study, we have performed a global proteomic analysis...

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Literature Corpus work: bbadf040-c54d-518d-a63e-fe30424f78a3
DOI: 10.64898/2025.12.02.691888

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