Article

The landscape of cellular clearance systems across human tissues and cell types is shaped by tissue-specific proteome needs

2024-08-26

Abstract excerpt

<h4>ABSTRACT</h4> Protein clearance is fundamental to proteome health. In eukaryotes, it is carried by two highly conserved proteolytic systems, the ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway (ALP). Despite their pivotal role, the basal organization of the human protein clearance systems across tissues and cell types remains uncharacterized. Here, we interrogated this organization using...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d26120a2-1e7f-5057-92c9-2018d72a3eaf
DOI: 10.1101/2024.08.26.609695

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The landscape of cellular clearance systems across human tissues and cell types is shaped by tissue-specific proteome needsDOI 10.1101/2024.08.26.609695Read

A Comprehensive Enumeration of the Human Proteostasis Network. 1. Components of Translation, Protein Folding, and Organelle-Specific SystemsSemantic proximity Read

Survey of the human proteostasis network: the ubiquitin-proteasome systemSemantic proximity Read

Deciphering the tissue specificity of the protein secretory pathway in humansSemantic proximity Read

Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesisSemantic proximity Read

Master regulators governing protein abundance across ten human cancer typesSemantic proximity Read

A Quantitative Proteome Map of the Human BodySemantic proximity Read

Spatial distribution of the proteome in human body and cancersSemantic proximity Read

A deep proteome and transcriptome abundance atlas of 29 healthy human tissuesSemantic proximity Read

Ubiquitin-mediated degradation of cellular proteins in health and disease.Semantic proximity Read

A better understanding of molecular mechanisms underlying human disease.Semantic proximity Read

Structure, Function, and Allosteric Regulation of the 20S Proteasome by the 11S/PA28 Family of Proteasome ActivatorsSemantic proximity Read