Article

Disruption of ubiquitin mediated proteolysis is a widespread mechanism of tumorigenesis

2018-12-28

Abstract excerpt

E3 ligases and degrons --the sequences they recognize in target proteins-- are key parts of the ubiquitin-mediated proteolysis system. There are several examples of alterations of these two components of the system that play a role in cancer. Here, we uncovered the landscape of the contribution of such alterations to tumorigenesis across cancer types. We first systematically identified novel instances of degrons a...

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Literature Corpus work: 7242985f-ef86-5a19-96bc-d9fc44ef6000
DOI: 10.1101/507764

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