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The Post-Translational Role of UFMylation in Physiology and Disease

29 Oct 2023

Abstract excerpt

Ubiquitin-fold modifier 1 (UFM1) is a newly identified ubiquitin-like protein that has been conserved during the evolution of multicellular organisms. In a similar manner to ubiquitin, UFM1 can become covalently linked to the lysine residue of a substrate via a dedicated enzymatic cascade. Although a limited number of substrates have been identified so far, UFM1 modification (UFMylation) has been demonstrated to...

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PMID: 37947621
DOI: 10.3390/cells12212543

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