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Article

Extreme Downregulation of Chromosome Y and Cancer Risk in Men.

Journal of the National Cancer Institute - 1 Sept 2020

Cáceres Alejandro, Jene Aina, Esko Tonu, Pérez-Jurado Luis A, González Juan R

Abstract excerpt

BACKGROUND: Understanding the biological differences between sexes in cancer is essential for personalized treatment and prevention. We hypothesized that the extreme downregulation of chromosome Y gene expression (EDY) is a signature of cancer risk in men and the functional mediator of the reported association between the mosaic loss of chromosome Y (LOY) and cancer. METHODS: We advanced a method to measure EDY...

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Share to Chromosomes, Human, Y
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31945786
DOI: 10.1093/jnci/djz232
PMCID: PMC7492764

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