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Organ-specific immune responses are strain-dependent in a mouse model of <i>Cryptococcus neoformans</i> brain infection

2025-07-22

Abstract excerpt

Cryptococcal meningitis remains the top cause of death from an invasive fungal infection in humans, responsible for ∼100,000 deaths annually of vulnerable patients with underlying immune deficiencies. Animal models of cryptococcal meningitis are important for understanding the immune parameters that correlate with protection. However, modelling this infection in mice is challenging. There is wide variability in in...

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Literature Corpus work
ce2fb059-587b-54a0-a2ec-564665501f09
DOI
10.1101/2025.07.18.665331
Open publication

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Organ-specific immune responses are strain-dependent in a mouse model of <i>Cryptococcus neoformans</i> brain infectionDOI 10.1101/2025.07.18.665331
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