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Article

Cryptococcus inositol utilization modulates the host protective immune response during brain infection.

Cell communication and signaling : CCS - 10 Sept 2014

Liu Tong-Bao, Subbian Selvakumar, Pan Weihua, Eugenin Eliseo, Xie Jianping, Xue Chaoyang

Abstract excerpt

BACKGROUND: Cryptococcus neoformans is the most common cause of fungal meningitis among individuals with HIV/AIDS, which is uniformly fatal without proper treatment. The underlying mechanism of disease development in the brain that leads to cryptococcal meningoencephalitis remains incompletely understood. We have previously demonstrated that inositol transporters (ITR) are required for Cryptococcus virulence. The...

Topics

Animals
Brain Diseases
Cryptococcosis
Cryptococcus neoformans
Female
Gene Expression Profiling
Gene Regulatory Networks
Host-Pathogen Interactions
Inositol
Interferon-gamma
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polysaccharides

Real-Time Polymerase Chain Reaction

Sequence Analysis, RNA

Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 25201772
DOI: 10.1186/s12964-014-0051-0
PMCID: PMC4172957

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25201772-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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