Article

Using the Collaborative Cross to Dissect Immunological Mechanisms Governing Latent Infection, Granuloma Formation, and Neuroinvasive Disease Following Repeated Very Low-Dose Inhalation Exposure to Cryptococcus

2026-06-16

Abstract excerpt

<h4>Background</h4> Decades of cryptococcal research have relied on a small number of hypervirulent laboratory strains, principally H99 and its derivatives, which cause rapid and lethal central nervous system infection and bypass the latent pulmonary phase that defines the natural history of human disease. As a result, the immune mechanisms that govern durable fungal containment in the lung, the reasons these mec...

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Literature Corpus work: caa17112-6639-50e8-a865-bac4f4139d85
DOI: 10.64898/2026.06.12.731915

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