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Inbred SJL mice recapitulate human resistance to Cryptococcus infection due to differential immune activation

6 Oct 2023

Abstract excerpt

ABSTRACT Cryptococcosis remains a significant threat to human health. While the popular C57BL/6J mouse model of cryptococcosis has some advantages, there are some serious shortcomings that limit the ability of researchers to address the disease. Since humans are resistant to environmental cryptococcal infection until rendered immunodeficient while C57BL/6J mice are innately susceptible, we screened 15 inbred...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 37800917
DOI: 10.1128/mbio.02123-23

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