Article

Lack of an atypical PDR transporter generates an immunogenic <i>Cryptococcus neoformans</i> strain that drives a dysregulated and lethal immune response in murine lungs

2024-06-17

Abstract excerpt

<h4>ABSTRACT</h4> Cryptococcus neoformans is an opportunistic fungal pathogen responsible for >150,000 deaths every year with a mortality rate as high as 81%. This high medical burden is due, in part, to an incomplete understanding of its pathogenesis. In a previous study, we identified a cryptococcal atypical ATP-binding cassette (ABC) pleiotropic drug resistance (PDR) transporter, PDR6 , that affected antifung...

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Literature Corpus work: a57220b3-871f-5dcd-a722-c94dbf087e74
DOI: 10.1101/2024.06.17.599354

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