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Article

Identification of genes from the fungal pathogen Cryptococcus neoformans related to transmigration into the central nervous system.

PloS one - 1 Jan 2012

Tseng Hsiang-Kuang, Liu Chang-Pan, Price Michael S, Jong Ambrose Y, Chang Jui-Chih, Toffaletti Dena L, Betancourt-Quiroz Marisol, Frazzitta Aubrey E, Cho Wen-Long, Perfect John R

Abstract excerpt

BACKGROUND: A mouse brain transmigration assessment (MBTA) was created to investigate the central nervous system (CNS) pathogenesis of cryptococcal meningoencephalitis. METHODOLOGY/PRINCIPAL FINDINGS: Two cryptococcal mutants were identified from a pool of 109 pre-selected mutants that were signature-tagged with the nourseothricin acetyltransferase (NAT) resistance cassette. These two mutants displayed abnormal...

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PMID: 23028773
DOI: 10.1371/journal.pone.0045083
PMCID: PMC3447876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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