Article

Closely related <i>Cryptococcus neoformans</i> strains possess differential virulence both in humans and the mouse inhalation model

2019-01-18

Abstract excerpt

Cryptococcal meningitis (CM) causes high rates of HIV-related mortality, yet Cryptococcus factors influencing patient outcome are not well understood. Pathogen-specific traits, such as the strain genotype and degree of antigen shedding, are associated with clinical outcome but the underlying biology remains elusive. In this study, we examined factors determining disease outcome in HIV-infected cryptococcal mening...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 179060e2-ca92-5e0d-8885-79daba88f836
DOI: 10.1101/524165

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Closely related <i>Cryptococcus neoformans</i> strains possess differential virulence both in humans and the mouse inhalation modelDOI 10.1101/524165Read

The Mouse Inhalation Model of Cryptococcus neoformans Infection Recapitulates Strain Virulence in Humans and Shows that Closely Related Strains Can Possess Differential VirulenceSemantic proximity Read

Organ-specific immune responses are strain-dependent in a mouse model of <i>Cryptococcus neoformans</i> brain infectionSemantic proximity Read

Global proteomic analysis of <i>Cryptococcus neoformans</i> clinical strains reveals significant differences between latent and lethal infectionSemantic proximity Read

Genetic and environmental influences on the evolution of virulence in the HIV-associated opportunistic human fungal pathogen <i>Cryptococcus neoformans</i>Semantic proximity Read

Identification of pathogen genomic differences that impact human immune response and disease during <i>Cryptococcus neoformans</i> infectionSemantic proximity Read

Cryptococcus neoformans Genotypic Diversity and Disease Outcome among HIV Patients in AfricaSemantic proximity Read

Assessing the virulence of <i>Cryptococcus neoformans</i> causing meningitis in HIV infected and uninfected patients in VietnamSemantic proximity Read

Identification of Pathogen Genomic Differences That Impact Human Immune Response and Disease during Cryptococcus neoformans InfectionSemantic proximity Read

Assessing the virulence of Cryptococcus neoformans causing meningitis in HIV infected and uninfected patients in Vietnam.Semantic proximity Read

The Biology of the<i>Cryptococcus neoformans</i>Species ComplexSemantic proximity Read

Virulence factors identified by Cryptococcus neoformans mutant screen differentially modulate lung immune responses and brain dissemination.Semantic proximity Read

Genomic variation across a clinical <i>Cryptococcus</i> population linked to disease outcomeSemantic proximity Read