Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Virulence factors identified by Cryptococcus neoformans mutant screen differentially modulate lung immune responses and brain dissemination.

The American journal of pathology - 1 Oct 2012

He Xiumiao, Lyons Daniel M, Toffaletti Dena L, Wang Fuyuan, Qiu Yafeng, Davis Michael J, Meister Daniel L, Dayrit Jeremy K, Lee Anthony, Osterholzer John J, Perfect John R, Olszewski Michal A

Abstract excerpt

Deletions of cryptococcal PIK1, RUB1, and ENA1 genes independently rendered defects in yeast survival in human CSF and within macrophages. We evaluated virulence potential of these genes by comparing wild-type Cryptococcus neoformans strain H99 with deletant and complement strains in a BALB/c mouse model of pulmonary infection. Survival of infected mice; pulmonary cryptococcal growth and pathology; immunological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cryptococcus neoformans
Share to Genes, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leukocyte Common Antigens

Share to Leukocytes

Share to Macrophage Activation

Share to Mice, Inbred BALB C

Share to Virulence Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 22846723
DOI: 10.1016/j.ajpath.2012.06.012
PMCID: PMC3463625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Virulence factors identified by Cryptococcus neoformans mutant screen differentially modulate lung immune responses and brain dissemination.PMID 22846723Read ↗

Phenotypic landscape of a fungal meningitis pathogen reveals its unique biologySemantic proximity Read ↗

Phenotypic landscape of an invasive fungal pathogen reveals its unique biology.Semantic proximity Read ↗

Associations between Cryptococcus Genotypes, Phenotypes, and Clinical Parameters of Human Disease: A ReviewSemantic proximity Read ↗

Cryptococcus inositol utilization modulates the host protective immune response during brain infection.Semantic proximity Read ↗

Infectious particle identity determines dissemination and disease outcome for the inhaled human fungal pathogen CryptococcusSemantic proximity Read ↗

Identification of Pathogen Genomic Differences That Impact Human Immune Response and Disease during Cryptococcus neoformans InfectionSemantic proximity Read ↗

CNLAC1 is required for extrapulmonary dissemination of Cryptococcus neoformans but not pulmonary persistence.Semantic proximity Read ↗

Identification of ENA1 as a Virulence Gene of the Human Pathogenic Fungus Cryptococcus neoformans through Signature-Tagged Insertional MutagenesisSemantic proximity Read ↗

Global proteomic analysis of <i>Cryptococcus neoformans</i> clinical strains reveals significant differences between latent and lethal infectionSemantic proximity Read ↗

Cryptococcal pathogenic mechanisms: a dangerous trip from the environment to the brainSemantic proximity Read ↗

Organ-specific immune responses are strain-dependent in a mouse model of <i>Cryptococcus neoformans</i> brain infectionSemantic proximity Read ↗

Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.