Article

OxPhos in adipose tissue macrophages regulated by BTK enhances their M2-like phenotype and confers a systemic immunometabolic benefit in obesity

2023-10-11

Abstract excerpt

Bruton’s tyrosine kinase (BTK) is a non-receptor bound kinase involved in pro-inflammatory signalling in activated macrophages, however, its role within adipose tissue macrophages remains unclear. We have demonstrated that BTK signalling regulates macrophage M2-like polarisation state by up-regulating subunits of mitochondrially encoded electron transport chain Complex I ( ND4 and NDL4 ) and Complex IV ( mt-CO1...

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Literature Corpus work: ce2af806-75ab-5380-87fd-cacea23b1090
DOI: 10.1101/2023.10.09.561199

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OxPhos in adipose tissue macrophages regulated by BTK enhances their M2-like phenotype and confers a systemic immunometabolic benefit in obesityDOI 10.1101/2023.10.09.561199Read

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