Regulatory T cell differentiation is controlled by αKG-induced alterations in mitochondrial metabolism and lipid homeostasis.

doi:10.1016/j.celrep.2021.109911

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Article

Regulatory T cell differentiation is controlled by αKG-induced alterations in mitochondrial metabolism and lipid homeostasis.

Cell reports - 2 Nov 2021

Matias Maria I, Yong Carmen S, Foroushani Amir, Goldsmith Chloe, Mongellaz Cédric, Sezgin Erdinc, Levental Kandice R, Talebi Ali, Perrault Julie, Rivière Anais, Dehairs Jonas, Delos Océane, Bertand-Michel Justine, Portais Jean-Charles, Wong Madeline, Marie Julien C, Kelekar Ameeta, Kinet Sandrina, Zimmermann Valérie S, Levental Ilya, Yvan-Charvet Laurent, Swinnen Johannes V, Muljo Stefan A, Hernandez-Vargas Hector, Tardito Saverio, Taylor Naomi, Dardalhon Valérie

Abstract excerpt

Suppressive regulatory T cell (Treg) differentiation is controlled by diverse immunometabolic signaling pathways and intracellular metabolites. Here we show that cell-permeable α-ketoglutarate (αKG) alters the DNA methylation profile of naive CD4 T cells activated under Treg polarizing conditions, markedly attenuating FoxP3+ Treg differentiation and increasing inflammatory cytokines. Adoptive transfer of these...

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Identifiers

PMID: 34731632
DOI: 10.1016/j.celrep.2021.109911
PMCID: PMC10167917

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