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Enhanced catabolism of branched-chain amino acids uncouples anti-inflammatory and antioxidant functions in liver macrophages

2025-12-11

Abstract excerpt

<title>Abstract</title> <p>Background Metabolic dysfunction–associated steatotic liver disease (MASLD) is marked by inflammation mediated by resident liver macrophages (RLMs). Branched-chain amino acids (BCAAs; leucine, isoleucine, valine) are elevated in early MASLD, yet their role in RLM biology is unclear. Aim We investigated whether BCAA exposure and impaired catabolism affect LPS-induced RLMs activation. Met...

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Literature Corpus work
d90f0e03-e2b9-55c5-a6ce-8551adb8e467
DOI
10.21203/rs.3.rs-8077254/v1
Open publication

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Enhanced catabolism of branched-chain amino acids uncouples anti-inflammatory and antioxidant functions in liver macrophagesDOI 10.21203/rs.3.rs-8077254/v1
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