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Article

Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses.

Diabetologia - 1 Apr 2018

Boutens Lily, Hooiveld Guido J, Dhingra Sourabh, Cramer Robert A, Netea Mihai G, Stienstra Rinke

Abstract excerpt

AIMS/HYPOTHESIS: Recent studies have identified intracellular metabolism as a fundamental determinant of macrophage function. In obesity, proinflammatory macrophages accumulate in adipose tissue and trigger chronic low-grade inflammation, that promotes the development of systemic insulin resistance, yet changes in their intracellular energy metabolism are currently unknown. We therefore set out to study metabolic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29333574
DOI: 10.1007/s00125-017-4526-6
PMCID: PMC6448980

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