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The Histone Demethylase KDM6B Governs the LYVE1+ Perivascular Macrophage Phenotype to Control Adipose Tissue Expandability through BMP2 signaling

2025-12-12

Abstract excerpt

<title>Abstract</title> <p>The capacity of white adipose tissue (WAT) to expand in response to energy surplus is a key factor in determining metabolic health. In obesity, this expansion becomes dysregulated and contributes to metabolic dysfunction, insulin resistance and type 2 diabetes. Phenotypically diverse subtypes of adipose tissue macrophages (ATMs) control WAT plasticity, yet the underlying regulatory mech...

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Literature Corpus work: 66f83edd-f476-5fd8-a459-b7d822b887bb
DOI: 10.21203/rs.3.rs-7071720/v1

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