Article

Inhibition of Bruton’s tyrosine kinase reduces NF-kB and NLRP3 inflammasome activity preventing insulin resistance and microvascular disease

2019-08-28

Abstract excerpt

Activation of inflammatory pathways in myeloid cells initiates insulin resistance leading to the development of type-2 diabetes and microvascular disease. Currently, there are no therapies available that target inflammation in T2D or microvascular disease. In the present study we investigate if Bruton’s tyrosine kinase (BTK) may represent a novel therapeutic target using the FDA approved medication ibrutinib. Ibru...

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Literature Corpus work: ce75489f-db2d-5540-ae25-297e47397bc3
DOI: 10.1101/745943

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