Article

A20 restriction of nitric oxide production restores macrophage bioenergetic balance

2025-10-27

Abstract excerpt

Macrophages play critical roles in regulating host responses to microbial pathogens and other forms of tissue stress and can acquire pro-inflammatory or tissue reparative phenotypes. A20, or TNFAIP3, is a potent regulator of innate immune cell functions and is extensively linked to human inflammatory and autoimmune diseases. We now find that A20 is a powerful regulator of both glycolytic and mitochondrial respirat...

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Literature Corpus work: 1c2fe76a-4fc0-54ce-90c5-04ecd271659f
DOI: 10.1101/2025.10.26.684676

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