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Article

TBC1D1 is an energy-responsive polarization regulator of macrophages via governing ROS production in obesity.

Science China. Life sciences - 1 Sept 2024

Wang Qi, Rong Ping, Zhang Wen, Yang Xinyu, Chen Liang, Cao Ye, Liu Minjun, Feng Weikuan, Ouyang Qian, Chen Qiaoli, Li Hailong, Liang Hui, Meng Fanguo, Wang Hong-Yu, Chen Shuai

Abstract excerpt

Energy status is linked to the production of reactive oxygen species (ROS) in macrophages, which is elevated in obesity. However, it is unclear how ROS production is upregulated in macrophages in response to energy overload for mediating the development of obesity. Here, we show that the Rab-GTPase activating protein (RabGAP) TBC1D1, a substrate of the energy sensor AMP-activated protein kinase (AMPK), is a...

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Identifiers

PMID: 38902450
DOI: 10.1007/s11427-024-2628-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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