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Article

Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages.

Cell metabolism - 7 Oct 2014

Kratz Mario, Coats Brittney R, Hisert Katherine B, Hagman Derek, Mutskov Vesco, Peris Eduard, Schoenfelt Kelly Q, Kuzma Jessica N, Larson Ilona, Billing Peter S, Landerholm Robert W, Crouthamel Matthew, Gozal David, Hwang Seungmin, Singh Pradeep K, Becker Lev

Abstract excerpt

Adipose tissue macrophage (ATM)-driven inflammation plays a key role in insulin resistance; however, factors activating ATMs are poorly understood. Using a proteomics approach, we show that markers of classical activation are absent on ATMs from obese humans but are readily detectable on airway macrophages of patients with cystic fibrosis, a disease associated with chronic bacterial infection. Moreover, treating...

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Source

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Identifiers

PMID: 25242226
DOI: 10.1016/j.cmet.2014.08.010
PMCID: PMC4192131

Genes

ATM
SQSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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