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MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer

16 Jan 2020

Abstract excerpt

BACKGROUND: Recent studies have suggested that fatty acid oxidation (FAO) is a key metabolic pathway for the growth of triple negative breast cancers (TNBCs), particularly those that have high expression of MYC. However, the underlying mechanism by which MYC promotes FAO remains poorly understood. METHODS: We used a combination of metabolomics, transcriptomics, bioinformatics, and microscopy to elucidate a...

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PMID: 31942031
DOI: 10.1038/s41416-019-0711-3

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