Article

Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation

2021-10-02

Abstract excerpt

<h4>Summary</h4> Activating macrophage NLRP3 inflammasome can promote excessive inflammation, with severe cell and tissue damage and organ dysfunction. Here, we show that pharmacological or genetic inhibition of pyruvate dehydrogenase kinase (PDHK) significantly attenuates NLRP3 inflammasome activation in murine and human macrophages and septic mice by lowering caspase-1 cleavage and IL-1β secretion. Inhibiting P...

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Literature Corpus work: f826c1e0-51ea-5b5f-98be-f81029e939cd
DOI: 10.1101/2021.10.02.462869

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