Article

NuMA deficiency causes micronuclei via checkpoint-insensitive k-fiber minus-end detachment from mitotic spindle poles

2022-10-05

Abstract excerpt

Micronuclei resulting from improper chromosome segregation foster chromosomal instability in somatic cell division cycles. To prevent micronuclei formation, bundled kinetochore-microtubules called k-fibers must be properly connected to all sister kinetochores on chromosomes via their plus-ends, whereas k-fiber minus-ends must be clustered at the two opposing spindle poles throughout mitosis. The bipolar attachment...

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Literature Corpus work: ce1b0f4b-74ec-52d8-bdcd-5739f4e24258
DOI: 10.1101/2022.10.04.510904

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