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Double-checking chromosome segregation

25 Mar 2023

Abstract excerpt

Enduring chromosome segregation errors represent potential threats to genomic stability due to eventual chromosome copy number alterations (aneuploidy) and formation of micronuclei-key intermediates of a rapid mutational process known as chromothripsis that is found in cancer and congenital disorders. The spindle assembly checkpoint (SAC) has been viewed as the sole surveillance mechanism that prevents chromosome...

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PMID: 37017932
DOI: 10.1083/jcb.202301106

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