Article

Ran-GTP is non-essential to activate NuMA for spindle pole focusing, but dynamically polarizes HURP to control mitotic spindle length

2018-11-19

Abstract excerpt

During mitosis, a bipolar spindle is assembled around chromosomes to efficiently capture chromosomes. Previous work proposed that a chromosome-derived Ran-GTP gradient promotes spindle assembly around chromosomes by liberating spindle assembly factors (SAFs) from inhibitory importins. However, Ran’s dual functions in interphase nucleocytoplasmic transport and mitotic spindle assembly have made it difficult to asse...

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Literature Corpus work: 814f54ae-8337-51d8-80ca-639861453bec
DOI: 10.1101/473538

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