Kinetochore Malfunction in Human Pathologies.

doi:10.1007/978-3-319-57127-0_4

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Article

Kinetochore Malfunction in Human Pathologies.

Advances in experimental medicine and biology - 1 Jan 2017

de Wolf Bas, Kops Geert J P L

Abstract excerpt

The cell cycle culminates in mitosis with the purpose of dividing the cell's DNA content equally over two daughter cells. Error-free segregation relies on correct connections between chromosomes and spindle microtubules. Kinetochores are complex multi-protein assemblies that mediate these connections and are the platforms for attachment-error-correction and spindle assembly checkpoint signaling. Proper...

Topics

Aneuploidy
Animals
Chromosomal Instability
Chromosome Segregation
Genetic Predisposition to Disease
Humans
Kinetochores
Microcephaly
Mitosis
Mutation
Neoplasms

Source

Open in PubMed

Identifiers

PMID: 28600783
DOI: 10.1007/978-3-319-57127-0_4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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