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Article

A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division.

Communications biology - 19 Mar 2021

Owa Mikito, Dynlacht Brian

Abstract excerpt

Centromere-associated protein-E (CENP-E) is a kinesin motor localizing at kinetochores. Although its mitotic functions have been well studied, it has been challenging to investigate direct consequences of CENP-E removal using conventional methods because CENP-E depletion resulted in mitotic arrest. In this study, we harnessed an auxin-inducible degron system to achieve acute degradation of CENP-E. We revealed a...

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Identifiers

PMID: 33742057
DOI: 10.1038/s42003-021-01861-4
PMCID: PMC7979751

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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