Article

Genetic background shapes SEZ6L2 autoimmunity and reveals coordinated immune responses linked to neurological dysfunction

2026-04-03

Abstract excerpt

<h4>ABSTRACT</h4> SEZ6L2 autoantibodies have been identified in patients with subacute cerebellar ataxia, but the underlying immune mechanisms and pathogenic pathways remain poorly understood. We previously established a C57BL/6 mouse model of SEZ6L2 autoimmunity that recapitulates key features of the disease. Here, we evaluated whether genetic background influences the magnitude and organization of SEZ6L2-direct...

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Literature Corpus work: cdca6164-b1f2-505d-bfa3-8d0b9320eb84
DOI: 10.64898/2026.03.31.715689

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