Polyclonal lymphoid expansion drives paraneoplastic autoimmunity in neuroblastoma

Abstract excerpt

<h4>Summary</h4> Neuroblastoma is a lethal childhood solid tumor of developing peripheral nerves. Two percent of children with neuroblastoma develop Opsoclonus Myoclonus Ataxia Syndrome (OMAS), a paraneoplastic disease characterized by cerebellar and brainstem-directed autoimmunity, but typically with outstanding cancer-related outcomes. We compared tumor transcriptomes and tumor infiltrating T- and B-cell repert...

Topics

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• Autoimmune Neurological Disorders and Treatments
• Central Nervous System
• Central Nervous System Neoplasms
• Glioma Diagnosis and Treatment
• Lymphoma, Large B-Cell, Diffuse
• Mutation
• Myeloid Differentiation Factor 88
• Neuroblastoma Research and Treatments

Identifiers and source

Literature Corpus work

3bb7ae55-0dbd-5edb-9f15-927d557f4de8

DOI

10.1101/2021.12.14.471886