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Article

Polyclonal lymphoid expansion drives paraneoplastic autoimmunity in neuroblastoma

1 Aug 2023

Abstract excerpt

Neuroblastoma is a lethal childhood solid tumor of developing peripheral nerves. Two percent of children with neuroblastoma develop opsoclonus myoclonus ataxia syndrome (OMAS), a paraneoplastic disease characterized by cerebellar and brainstem-directed autoimmunity but typically with outstanding cancer-related outcomes. We compared tumor transcriptomes and tumor-infiltrating T and B cell repertoires from 38 OMAS...

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PMID: 37537844
DOI: 10.1016/j.celrep.2023.112879

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