Sez6L2 autoimmunity induces cerebellar ataxia in mice

Abstract excerpt

<h4>ABSTRACT</h4> Sez6L2 autoantibodies have been reported in patients with subacute cerebellar ataxia, presenting with gait disturbances, frequent falls, slurred speech, and repetitive eye movements. These case studies suggest that autoimmunity against Sez6L2 causes cerebellar damage leading to ataxia. Sez6L2 is a transmembrane protein expressed by most neurons, with the highest levels in the cerebellum. We test...

Topics

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• Autoantibodies
• Disease Models, Animal
• Methyl-CpG-Binding Protein 2
• Mice
• Mice, Inbred C57BL
• Mice, Transgenic
• Phenotype
• Proteinuria

Identifiers and source

Literature Corpus work

d2f3a76f-5545-53e5-9cab-c0203cb37e05

DOI

10.1101/2025.05.28.656724