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Article

Analysis of CNS autoimmunity in genetically diverse mice reveals unique phenotypes and mechanisms.

JCI insight - 8 Nov 2024

Nelson Emily A, Tyler Anna L, Lakusta-Wong Taylor, Lahue Karolyn G, Hankes Katherine C, Teuscher Cory, Lynch Rachel M, Ferris Martin T, Mahoney J Matthew, Krementsov Dimitry N

Abstract excerpt

Multiple sclerosis (MS) is a complex disease with significant heterogeneity in disease course and progression. Genetic studies have identified numerous loci associated with MS risk, but the genetic basis of disease progression remains elusive. To address this, we leveraged the Collaborative Cross (CC), a genetically diverse mouse strain panel, and experimental autoimmune encephalomyelitis (EAE). The 32 CC strains...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Encephalomyelitis, Autoimmune, Experimental

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Identifiers

PMID: 39325545
DOI: 10.1172/jci.insight.184138
PMCID: PMC11601571

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