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Article

Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1997

Mohan C, Morel L, Yang P, Wakeland E K

Abstract excerpt

Susceptibility to systemic lupus erythematosus in the NZM2410 murine model maps to Sle1, Sle2, Sle3, and the H2 loci. To unravel how these loci contribute to the pathogenesis of lupus, individual NZM2410-derived genomic intervals bearing these loci have been successfully backcrossed onto the resi...

Topics

Animals
B-Lymphocytes
Chromosome Mapping
Genetic Predisposition to Disease
Lupus Erythematosus, Systemic
Lymphocyte Activation
Mice
Mice, Inbred C57BL

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9200486

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9200486-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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