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Article

Identification of genetic determinants of the sexual dimorphism in CNS autoimmunity.

PloS one - 1 Jan 2015

Bearoff Frank, Case Laure K, Krementsov Dimitry N, Wall Emma H, Saligrama Naresha, Blankenhorn Elizabeth P, Teuscher Cory

Abstract excerpt

Multiple sclerosis (MS) is a debilitating chronic inflammatory disease of the nervous system that affects approximately 2.3 million individuals worldwide, with higher prevalence in females, and a strong genetic component. While over 200 MS susceptibility loci have been identified in GWAS, the underlying mechanisms whereby they contribute to disease susceptibility remains ill-defined. Forward genetics approaches...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25671658
DOI: 10.1371/journal.pone.0117993
PMCID: PMC4324900

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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